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师资队伍

博士生导师

邱振鹏个人简介

作者: 来源: 阅读次数: 日期:2023-11-25

简历

姓名:邱振鹏

学历/学位:博士研究生

职称:教授

教育经历:

2011/09 — 2014/12 武汉大学基础医学院,基础医学,博士

2009/09 — 2011/06 武汉大学8188www威尼斯,中药学,硕博连读转博

2005/09 — 2009/06 中南民族大学8188www威尼斯,药学,学士

工作经历:

2023/04 至今 湖北中医药大学8188www威尼斯,教授,博士生导师

2021/01 — 2023/03 湖北中医药大学8188www威尼斯,副教授,博士生导师

2018/09 — 2023/03 湖北中医药大学8188www威尼斯,副教授,硕士生导师

2017/06 — 2018/08 湖北中医药大学8188www威尼斯,讲师,硕士生导师

2015/07 — 2017/05 湖北中医药大学8188www威尼斯,讲师

教学与科学研究:

研究领域:(1)分子药理学;(2)天然药物药效学与毒理学研究;(3)中药药理学

研究兴趣:(1)慢性肝脏疾病(NAFLD、NASH、NAFLD-HCC)发生机制与药物干预研究;(2)基于脂肪酸代谢重编程的代谢相关疾病防治策略研究

博士研究生招生方向:

中药学(学术学位,招生代码:100800)

硕士研究生招生方向:

药理学(学术学位,招生代码:100706;专业学位招生代码:105500)

科研团队:

湖北中医药大学慢性肝脏疾病发病机制及靶向治疗研究团队,负责人;建设周期:2020/01-2023/12。

主持/参与主要科研项目:

1. 国家自然科学基金面上项目,82074077,鞣花鞣质代谢物urolithin A调控肝细胞脂代谢重编程与线粒体自噬抑制NAFLD相关肝癌发生的作用机制研究,2021/01-2024/12,主持;

2. 国家自然科学基金青年科学基金项目,81603338,鞣花鞣质代谢物urolithins通过NF-κB/PRL-3反馈环路抑制肝癌淋巴道转移机制研究,2017/01-2019/12,主持;

3. 湖北省自然科学基金面上项目,2017CFB483,中药余甘子改善II型糖尿病血管病变的药效学及作用机制研究,2017/01-2018/12,主持;

4. 湖北省教育厅科研计划项目,Q20162001,Methyl-urolithin A通过miR-21诱导前列腺癌细胞凋亡的分子机制,2016/01-2018/12,主持;

5. 湖北省技术创新专项(重大项目),治疗结节性甲状腺肿新药活血消瘿片的临床前研究,2017/01-2020/12,技术骨干;

6. 国家自然科学基金青年科学基金项目, AKT/Yap协同促进肝内胆管癌形成的分子作用机制研究,2017/01-2019/12,技术骨干;

7. 湖北省自然科学基金面上项目,雷公藤红素靶向AKT/mTOR调控糖代谢重编程抑制肝内胆管癌的作用机制研究,2020/07-2022/06,技术骨干;

学术兼职与同行评议:

1. 中华中医药学会中药实验药理分会,委员;

2. 湖北省药理学会,理事;

3. 湖北省毒理学会,理事;

4. 湖北省药理学会中药药理专业委员会,委员;

5. 武汉药学会老年药学专业委员会,委员;

6. 国家自然科学基金青年科学基金/面上项目通讯评审专家(2019,2020,2021,2022年度)

已发表的部分研究成果:

1. Liu, J.; Huang, X.; Zhang, F.; Luo, X.; Yu, W.; Li, C.; Qiu, Z.; Liu, Y.; Xu, Z., Metal-free multifunctional nanozymes mimicking endogenous antioxidant system for acute kidney injury alleviation. Chemical Engineering Journal 2023, 477, 147048. (Co-corresponding author

2. Yang, Y.; Xu, J.; Tu, J.; Sun, Y.; Zhang, C.; Qiu, Z.; Xiao, H., Polygonum cuspidatum Sieb. et Zucc. Extracts improve sepsis-associated acute kidney injury by inhibiting NF-κB-mediated inflammation and pyroptosis. The Journal of Ethnopharmacology 2023, 319(Pt 1):117101. (Co-corresponding author

3. Cao, P.; Wang, Y.; Zhang, C.; Sullivan, M. A.; Chen, W.; Jing, X.; Yu, H.; Li, F.; Wang, Q.; Zhou, Z.; Wang, Q.; Tian, W.; Qiu, Z.; Luo, L., Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy. The Journal of Nutritional Biochemistry 2023, 120, 109414. (Co-corresponding author

4. Li, H.; Huang, X.; Zhang, F.; Luo, X.; Yu, W.; Li, C.; Jiang, B.; Qiu, Z.; Xu, Z., Specific discrimination of zinc and manganese ions by label free dual emissive carbon dots by ratio-metric mode. Talanta 2023, 260, 124627. (Co-corresponding author

5. Lu, Y.; Hu, J.; Chen, L.; Li, S.; Yuan, M.; Tian, X.; Cao, P.; Qiu, Z., Ferroptosis as an emerging therapeutic target in liver diseases. Frontiers in Pharmacology 2023, 14:1196287. (Last author

6. Zhang, C.; Song, Y.; Yuan, M.; Chen, L.; Zhang, Q.; Hu, J.; Meng, Y.; Li, S.; Zheng, G.; Qiu, Z., Ellagitannins-Derived Intestinal Microbial Metabolite Urolithin A Ameliorates Fructose-Driven Hepatosteatosis by Suppressing Hepatic Lipid Metabolic Reprogramming and Inducing Lipophagy. Journal of Agricultural and Food Chemistry 2023, 71 (9), 3967–3980. (Last author

7. Lu, Y.; Zhang, C.; Song, Y.; Chen, L.; Chen, X.; Zheng, G.; Yang, Y.; Cao, P.; Qiu, Z., Gallic acid impairs fructose-driven de novo lipogenesis and ameliorates hepatic steatosis via AMPK-dependent suppression of SREBP-1/ACC/FASN cascade. European Journal of Pharmacology 2023, 940, 175457. (Last author

8. Tan X.; Huang X.; Lu Z.; Chen L.; Hu J.; Tian X.; Qiu Z., The essential effect of mTORC1-dependent lipophagy in nonalcoholic fatty liver disease. Frontiers in Pharmacology 2023, 14 (Review Article). (Last author

9. Tan, X.; Sun, Y.; Chen, L.; Hu, J.; Meng, Y.; Yuan, M.; Wang, Q.; Li, S.; Zheng, G.; Qiu, Z., Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation. Journal of Agricultural and Food Chemistry 2022, 70 (20), 6108-6122. (Last author

10. Li, H.; Zhang, Q.; Luo, X.; Yao, Z.; Qu, Y.; Wang, E.; Jiang, B.; Qiu, Z.; Li, C.; Xu, Z., Intrinsic dual emissive carbon dots for ratiometric sensing of acetylcholinesterase fluctuation induced by organophosphorus pesticide intoxication. Sens. Actuators B: Chem. 2022, 373, 132590.(Co-corresponding author

11. Guo, W.; Luo, L.; Meng, Y.; Chen, W.; Yu, L.; Zhang, C.; Qiu, Z.; Cao, P., Luteolin alleviates methionine–choline-deficient diet-induced non-alcoholic steatohepatitis by modulating host serum metabolome and gut microbiome. Frontiers in Nutrition 2022, 9. (Co-corresponding author

12. Zhang, C.; Song, Y.; Chen, L.; Chen, P.; Yuan, M.; Meng, Y.; Wang, Q.; Zheng, G.; Qiu, Z., Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy. Frontiers in Pharmacology 2022, 13. (Last author

13. Zhang, C.; Lu, Y.; Song, Y.; Chen, L.; Hu, J.; Meng, Y.; Chen, X.; Li, S.; Zheng, G.; Qiu, Z., Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway. Journal of Cellular and Molecular Medicine 2022, 26 (14), 3995-4006. (Last author

14. Yi, S.; Zhang, C.; Hu, J.; Meng, Y.; Chen, L.; Yu, H.; Li, S.; Wang, G.; Zheng, G.; Qiu, Z., Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes. AAPS PharmSciTech 2021, 22 (1), 26. (Last author

15. Zhang, C.; Sheng, L.; Yuan, M.; Hu, J.; Meng, Y.; Wu, Y.; Chen, L.; Yu, H.; Li, S.; Zheng, G.; Qiu, Z., Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met. Toxicology and Applied Pharmacology 2020, 392, 114918. (Last author

16. Zhang, C.; Hu, J.; Sheng, L.; Yuan, M.; Wu, Y.; Chen, L.; Wang, G.; Qiu, Z., Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT/SREBP-1/FASN pathway. Food & Function 2019, 10 (6), 3410-3420. (Last author

17. Qiu, Z.; Zhang, C.; Zhou, J.; Hu, J.; Sheng, L.; Li, X.; Chen, L.; Li, X.; Deng, X.; Zheng, G., Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. Molecular Carcinogenesis 2019, 58 (1), 31-41. (Co-first author

18. Zhang, C.; Hu, J.; Sheng, L.; Yuan, M.; Wu, Y.; Chen, L.; Zheng, G.; Qiu, Z., Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation. Toxicology and Applied Pharmacology 2019, 365, 51-60. (Last author

19. Zhang, C.; Zhou, J.; Hu, J.; Lei, S.; Yuan, M.; Chen, L.; Wang, G.; Qiu, Z., Celecoxib attenuates hepatocellular proliferative capacity during hepatocarcinogenesis by modulating a PTEN/NF-κB/PRL-3 pathway. RSC Advances 2019, 9 (36), 20624-20632. (Last author

20. Hu, J.; Li, X.; Zhou, J.; Zhang, C.; Zheng, G.; Qiu, Z., Celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model via suppressing fatty acid synthase expression and AKT/ERK phosphorylation. RSC Advances 2018, 8 (25), 13976-13983. (Last author

21. Zhou, J.; Zhang, C.; Zheng, G.; Qiu, Z., Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A. Evidence-Based Complementary and Alternative Medicine 2018, 8478943. (Last author

22. Zhou, B.; Wang, J.; Zheng, G.; Qiu, Z., Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21. Food and Chemical Toxicology 2016, 97, 375-384. (Last author

23. Zhang, L.; Tu, Y.; He, W.; Peng, Y.; Qiu, Z., A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation. European Journal of Pharmacology 2015, 762, 55-62. (Last author

24. Zhou, B.; Yi, H.; Tan, J.; Wu, Y.; Liu, G.; Qiu, Z., Anti-Proliferative Effects of Polyphenols from Pomegranate Rind (Punica granatum L.) on EJ Bladder Cancer Cells Via Regulation of p53/miR-34a Axis. Phytotherapy Research 2015, 29 (3), 415-422. (Last author

25. Qiu, Z.; Zhou, B.; Jin, L.; Yu, H.; Liu, L.; Liu, Y.; Qin, C.; Xie, S.; Zhu, F., In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food and Chemical Toxicology 2013, 59, 428-437. (Co-first author

指导本科生、研究生获奖:

1. 鲁谕蓁等,2023年全国“挑战杯”大学生课外学术科技作品竞赛,三等奖;

2. 鲁谕蓁等,2023年湖北省第十四届“挑战杯”大学生课外学术科技作品竞赛,特等奖;

3. 孙懿等,2021年湖北中医药大学“挑战杯”大学生课外学术科技作品竞赛,二等奖;

4. 张聪等,2018年湖北省大学生创业大赛创业计划竞赛,铜奖。

(更新于2023年11月)

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